CD-Rom connected to another client (VMWare vSphere ESX)

Summary:

VM will not vMotion because CD-rom is detected as mounted by another user.  Option to disconnect or remove CD-rom is unavailable/grayed out under settings of VM.

CDROM connected

Resolution:

Open the VM’s Console, select the CD-rom drive icon and select disconnect.

Disconnect CDROM

As obvious as this seems, I found myself chasing a rabbit trying out methods to fix this issue.  This method worked in vSphere 4.1 Update 1.  Later revisions should too, not sure about earlier versions.